Sorger Lab

Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, Lograsso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, and Gray NS (2012). Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem Biol 19(1), 140-154. PMC3270411 PMID: 22284361. Abstract […]

Aldridge BB, Gaudet S, Lauffenburger DA, and Sorger PK (2011). Lyapunov Exponents and Phase Diagrams Reveal Multi-Factorial Control over Trail-Induced Apoptosis. Mol Syst Biol 7, 553. PMID: 22108795. Abstract

Receptor-mediated apoptosis proceeds via two pathways: one requiring only a cascade of initiator and effector caspases (type I behavior) and the second requiring an initiator-effector caspase […]

Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, and Sorger PK (2011). Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding. Mol Cell 43, 723-737. PMC3222462. Abstract

Epidermal growth factor receptors (ErbB1-4) are oncogenic receptor tyrosine kinases (RTKs) that regulate diverse cellular processes. In this study, we combine measurement and mathematical modeling […]

Saez-Rodriguez J, Alexopoulos L, Zhang M, Morris MK, Lauffenburger DA, and Sorger PK (2011). Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models. Cancer Res PMC3207250 Abstract

Substantial effort in recent years has been devoted to constructing and analyzing large-scale gene and protein networks based on ‘omic data and literature mining. These […]

Spencer SL, and Sorger PK (2011). Measuring and Modeling Apoptosis in Single Cells. Cell 144, 926-939. PMC3087303 Abstract

Cell death plays an essential role in the development of tissues and organisms, the etiology of disease, and the responses of cells to therapeutic drugs. Here we review progress made over the last decade in using mathematical […]