Sorger Lab

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, and Weissleder R (2013). Single-Cell and Subcellular Pharmacokinetic Imaging Allows Insight into Drug Action in Vivo. Nat Commun 4(1504. PMC3579506 PMID: 23422672. Abstract

Pharmacokinetic analysis at the organ level provides insight into how drugs distribute throughout the body, but cannot explain how drugs […]

Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, and Sorger PK (2013). Properties of Cell Death Models Calibrated and Compared Using Bayesian Approaches. Mol Syst Biol 9(644). PMC3588908 PMID: 23385484. Abstract

Using models to simulate and analyze biological networks requires principled approaches to parameter estimation and model discrimination. We use Bayesian and Monte […]

Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, and Macbeath G (2013). Phosphotyrosine Signaling Proteins That Drive Oncogenesis Tend To Be Highly Interconnected. Mol Cell Proteomics PMC3650332 PMID: 23358503. Abstract

Mutation and over-expression of Receptor Tyrosine Kinases or the proteins they regulate serve as oncogenic drivers in diverse cancers. To better understand RTK […]

Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, and Yaffe MB (2012). Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks. Cell 149(4), 780-794. PMC3501264 PMID: 22579283. Abstract

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes limit component-by-component approaches to understanding human disease. Network […]

Gaudet S, Spencer SL, Chen WW, and Sorger PK (2012). Exploring the Contextual Sensitivity of Factors That Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis. PLoS Comput Biol 8(4), e1002482. PMC3343095 PMID: 22570596. Abstract

Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL […]