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Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, and Sorger PK (2013). Metrics Other Than Potency Reveal Systematic Variation in Responses to Cancer Drugs. Nat Chem Biol 9(11), 708-714. PMC3947796 PMID: 24013279. Abstract Large-scale analysis of cellular response to anticancer drugs typically focuses on variation in potency (half-maximum inhibitory concentration, (IC50)), assuming that it is […] Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, and Sorger PK (2013). Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines. Sci Signal 6(294), ra84. PMC3845839 PMID: 24065145. Abstract Identifying factors responsible for variation in drug response is essential for the effective use […] Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, and Letai A (2013). BID Preferentially Activates BAK While BIM Preferentially Activates BAX, Affecting Chemotherapy Response. Mol Cell 51(6), 751-765. PMID: 24074954. Abstract Apoptosis is a highly regulated form of cell death that controls normal homeostasis as […] Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, and Stuart JM (2013). Discovering Causal Pathways Linking Genomic Events to Transcriptional States Using Tied Diffusion through Interacting Events (TieDIE). Bioinformatics PMC3799471 PMID: 23986566. Abstract MOTIVATION: Identifying the cellular wiring that connects genomic perturbations to transcriptional changes in cancer is essential to gain a mechanistic […] Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, and Danuser G (2013). S. Cerevisiae Chromosomes Biorient Via Gradual Resolution of Syntely between S Phase and Anaphase. Cell 154(5), 1127-1139. PMC3802543 PMID: 23993100. Abstract Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister […] Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, Macbeath G, and Sorger P (2013). Profiling Phospho-Signaling Networks in Breast Cancer Using Reverse-Phase Protein Arrays. Oncogene PMC3670968 PMID: 22945653. Abstract Measuring the states of cell signaling pathways in tumor samples promises to advance the understanding of oncogenesis and identify response biomarkers. Here, we describe […] Flusberg DA, and Sorger PK (2013). Modulating Cell-to-Cell Variability and Sensitivity to Death Ligands by Co-Drugging. Phys Biol 10(3), 035002. PMC3775495 PMID: 23735516. Abstract TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) holds promise as an anti-cancer therapeutic but efficiently induces apoptosis in only a subset of tumor cell lines. Moreover, even in clonal populations of responsive […] Bagci-Onder T, Agarwal A, Flusberg D, Wanningen S, Sorger P, and Shah K (2013). Real-Time Imaging of the Dynamics of Death Receptors and Therapeutics That Overcome TRAIL Resistance in Tumors. Oncogene PMC3676868 PMID: 22824792. Abstract Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis specifically in tumor cells and its efficacy has been tested in […] Flusberg DA, Roux J, Spencer SL, and Sorger PK (2013). Cells Surviving Fractional Killing by TRAIL Exhibit Transient but Sustainable Resistance and Inflammatory Phenotypes. Mol Biol Cell PMC3708725 PMID: 23699397. Abstract When clonal populations of human cells are exposed to apoptosis-inducing agents, some cells die and others survive. This fractional killing arises not from mutation […] McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, and Gygi SP (2013). Mass Spectrometry Based Method to Increase Throughput for Kinome Analyses Using ATP Probes. Anal Chem 85(9), 4666-4674. PMC3771683 PMID: 23607489. Abstract Protein kinases play critical roles in many biological and pathological processes, making them important targets for therapeutic drugs. Here, we […] |
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