Initiative in Systems Pharmacology

Today Harvard Medical School announced the launch of the Initiative in Systems Pharmacology (ISP), a comprehensive strategy to transform drug discovery by convening researchers from an unprecedented range of disciplines to explore together how drugs work in complex systems.

Many people in the Systems Biology Department have been working on this for a long time […]

Math Lens Sharpens Biological Picture

Scientific Challenge Supports Competing Views of Complex Living Systems

In an empirical science like biology, in which experimentation and observed results rule the day, should data speak for itself? Well, not necessarily, said Peter Sorger. It depends on your philosophy.

In the 4th century BC, Plato described data interpretation best—and first—with his Allegory of the […]

Random Resistance: Genetically Identical Cancer Cells Show Different Responses to Drug

In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups of people are studied in aggregate (conservatives, liberals, atheists, evangelicals), they appear to be fairly uniform and predictable. But when looked at one person at […]

Peter Sorger to speak at German Symposium on Systems Biology 2009

Peter Sorger will be speaking at the German Symposium on Systems Biology 2009 May 12-15, 2009 – Heidelberg.

Medill Reports: Drug’s effect on cancer cells may impact tumor treatment

Original article.

Video: For cancer cells, genetics alone is poor indicator for drug response

LabSpaces, Social Networking for the Sciences, posted the video of Sabrina discussing the Nature paper. Original article

For cancer cells, genetics alone is poor indicator for drug response

April 12, 2009 David Cameron Harvard Medical School In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups of people are studied in aggregate (conservatives, liberals, atheists, evangelicals), they appear to be fairly uniform and predictable. But when looked at one person at a time, individuals often break the preconceptions. Same with cells. Researchers tend to identify characteristics of particular cells by looking at millions at a time. As a result, they’ll find that, say, “group A” responds very well to a particular cancer treatment, whereas “group B” does not. They will then often compare group A to group B to find out why. […]

Harvard Medical Labcast Episode 8: Working the System

Harvard Medical Labcast of November 26, 2008 included an interview of Peter Sorger. Original podcast.

Systems Biology’s Awkward Adolescence

Bio-IT World, on September 12, 2007, published an article the development of the field of systems biology. The article mentions Merrimack Pharmaceuticals and Peter Sorger. Original artcle.

Friendster for Proteins

Robert Langreth and Matthew Herper 03.12.07

Understanding how the body’s tiny components communicate is opening up vast territory in drug research.

Peter Sorger spent eight years developing new laboratory gadgets and arcane mathematical theorems to explain how networks of genes and proteins can go awry, causing cancer, arthritis and other diseases. But when he went […]