Latest News
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FamPlex: A Resource for Entity Recognition and Relationship Resolution of Human Protein Families and Complexes in Biomedical Text Mining
June 28, 2018
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Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases
May 31, 2018
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A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling
March 19, 2018
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Inflammatory but not Mitogenic Contexts Prime Synovial Fibroblasts for Compensatory Signaling Responses to p38 Inhibition
March 6, 2018
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Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma
March 2, 2018
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Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
February 20, 2018
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Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy
December 14, 2017
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The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
November 24, 2017
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From Word Models to Executable Models of Signaling Networks Using Automated Assembly
November 24, 2017
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Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics
November 7, 2017
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Today Harvard Medical School announced the launch of the Initiative in Systems Pharmacology (ISP), a comprehensive strategy to transform drug discovery by convening researchers from an unprecedented range of disciplines to explore together how drugs work in complex systems.
Many people in the Systems Biology Department have been working on this for a long time […]
Scientific Challenge Supports Competing Views of Complex Living Systems
In an empirical science like biology, in which experimentation and observed results rule the day, should data speak for itself? Well, not necessarily, said Peter Sorger. It depends on your philosophy.
In the 4th century BC, Plato described data interpretation best—and first—with his Allegory of the […]
In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups of people are studied in aggregate (conservatives, liberals, atheists, evangelicals), they appear to be fairly uniform and predictable. But when looked at one person at […]
Peter Sorger will be speaking at the German Symposium on Systems Biology 2009 May 12-15, 2009 – Heidelberg.
LabSpaces, Social Networking for the Sciences, posted the video of Sabrina discussing the Nature paper. Original article
April 12, 2009 David Cameron Harvard Medical School In certain respects, cells are less like machines and more like people. True, they have lots of components, but they also have lots of personality. For example, when specific groups of people are studied in aggregate (conservatives, liberals, atheists, evangelicals), they appear to be fairly uniform and predictable. But when looked at one person at a time, individuals often break the preconceptions. Same with cells. Researchers tend to identify characteristics of particular cells by looking at millions at a time. As a result, they’ll find that, say, “group A” responds very well to a particular cancer treatment, whereas “group B” does not. They will then often compare group A to group B to find out why. […]
Harvard Medical Labcast of November 26, 2008 included an interview of Peter Sorger. Original podcast.
Bio-IT World, on September 12, 2007, published an article the development of the field of systems biology. The article mentions Merrimack Pharmaceuticals and Peter Sorger. Original artcle.
Robert Langreth and Matthew Herper 03.12.07
Understanding how the body’s tiny components communicate is opening up vast territory in drug research.
Peter Sorger spent eight years developing new laboratory gadgets and arcane mathematical theorems to explain how networks of genes and proteins can go awry, causing cancer, arthritis and other diseases. But when he went […]
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