|
|||||
|
Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS. Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. Bioorganic & medicinal chemistry [Internet]. 2016 Dec 7; PMID: 28038940; PMCID: 5484535 Abstract Targeted […] Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK. Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging. Current protocols in chemical biology. 2016 Dec 7;8(4):251–264. PMID: 27925668; PMCID: 5233430 Abstract Cyclic Immunofluorescence (CycIF) is a public-domain method for performing highly multiplexed immunofluorescence imaging using a conventional epifluorescence microscope. It uses simple reagents and existing […] Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nature chemical biology. 2017 Jan 1;13(1):38–45. PMID: 27820799; PMCID: 5372219 Abstract Activation of synovial fibroblasts (SFs) contributes to rheumatoid arthritis (RA) by damaging synovial membranes and generating inflammatory cytokines that recruit immune cells […] Duan Q, Reid SP, Clark NR, Wang Z, Fernandez NF, Rouillard AD, Readhead B, Tritsch SR, Hodos R, Hafner M, Niepel M, Sorger PK, Dudley JT, Bavari S, Panchal RG, Ma’ayan A. L1000CDS2: LINCS L1000 characteristic direction signatures search engine. NPJ systems biology and applications [Internet]. 2016 Aug 1;2. PMID: 28413689; PMCID: 5389891 Abstract The […] Shi T, Niepel M, McDermott JE, Gao Y, Nicora CD, Chrisler WB, Markillie LM, Petyuk VA, Smith RD, Rodland KD, Sorger PK, Qian WJ, Wiley HS. Conservation of Protein Abundance Patterns Reveals the Regulatory Architecture of the EGFR-MAPK Pathway. Sci Signal. 2016;9(436):rs6. Epub 2016/07/14. doi: 10.1126/scisignal.aaf0891. PMID: 27405981; PMCID: PMC5036860. Abstract Various genetic mutations associated […] Hafner M, Niepel M, Chung M, Sorger PK. Growth Rate Inhibition Metrics Correct for Confounders in Measuring Sensitivity to Cancer Drugs. Nat Methods. 2016;13(6):521-7. Epub 2016/05/03. doi: 10.1038/nmeth.3853. PMID: 27135972; PMCID: PMC4887336. Abstract Drug sensitivity and resistance are conventionally quantified by IC50 or Emax values, but these metrics are highly sensitive to the number of […] AlQuraishi M, Sorger PK. Reproducibility Will Only Come with Data Liberation. Science translational medicine. 2016;8(339):339ed7. Epub 2016/05/20. doi: 10.1126/scitranslmed.aaf0968. PMID: 27194726. Download PDF Tirosh I, Izar B, Prakadan SM, Wadsworth MH, 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli […] Lin JR, Fallahi-Sichani M, Sorger PK. Highly Multiplexed Imaging of Single Cells Using a High-throughput Cyclic Immunofluorescence Method. Nat Commun. 2015;6:8390. Epub 2015/09/25. doi: 10.1038/ncomms9390. PMID: 26399630; PMCID: PMC4587398. Abstract Single-cell analysis reveals aspects of cellular physiology not evident from population-based studies, particularly in the case of highly multiplexed methods such as mass cytometry (CyTOF) […] Roux J, Hafner M, Bandara S, Sims JJ, Hudson H, Chai D, Sorger PK. Fractional Killing Arises from Cell-to-cell Variability in Overcoming a Caspase Activity Threshold. Mol Syst Biol. 2015;11(5):803. Epub 2015/05/09. doi: 10.15252/msb.20145584. PMID: 25953765; PMCID: PMC4461398. Abstract When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a […] |
|||||
|
Copyright © 2025 President and Fellows of Harvard College Powered by WordPress & Atahualpa |
|||||
