Otto Krayer Professor of Systems Pharmacology
Department of Systems Biology, Harvard Medical School
Head of the Harvard Program in Therapeutic Science
Harvard Program in Therapeutic Science, Harvard Medical School
Department of Biological Engineering, MIT
Director and P.I.
NIGMS Cell Decision Process Center
Peter Sorger received his A.B. from Harvard College, Ph.D. from Trinity College Cambridge, U.K. and trained as a postdoctoral fellow with Harold Varmus and Andrew Murray at the University of California, San Francisco. Sorger is the Otto Krayer Professor of Systems Pharmacology at Harvard Medical School (HMS) and co-founder of the Open Microscopy Environment (OME), MIT’s Computational and Systems Biology Initiative (CSBi), the Council for Systems Biology in Boston (CSB2; www.csb2.org) and companies that include Merrimack Pharmaceuticals and Glencoe Software and serves on the scientific advisory and corporate boards of several other technology companies. He is director of the Center for Cell Decision Processes, an NIH Center of Excellence in Systems Biology and co-directs a new HMS program in Systems Pharmacology.
1. Sorger PK, Lewis MJ, Pelham HR. (1987) Heat shock factor is regulated differently in yeast and HeLa cells. Nature 329(6134): 81-4.
2. Sorger PK, Pelham HR. (1988) Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54(6): 855-64.
3. Sorger PK. (1990) Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell 62(4): 793-805.
4. Sorger PK, Murray AW. (1992) S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature 355(6358): 365-8.
5. Kaplan KB, Hyman AA, Sorger PK. (1997) Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91(4): 491-500.
6. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. (2000) Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 101(6): 635-45.
7. He X, Asthana S, Sorger PK. (2000) Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell 101(7): 763-75.
8. He X, Rines DR, Espelin CW, Sorger PK. (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2): 195-206.
9. Meraldi P, Draviam VM, Sorger PK. (2004) Timing and checkpoints in the regulation of mitotic progression. Dev Cell 7(1): 45-60.
10. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. (2006) The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124(6): 1225-39.
11. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. (2008) Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell 30(1): 11-25. PMC2858979
12. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. (2008) Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death. PLoS Biol 6(12): e299. PMC2592357
13. Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. (2009) Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol Syst Biol 5: 239. PMC2644173
14. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459(7245): 428-32. PMC2858974
15. Chen WW, Niepel M, and Sorger PK (2010). Classic and Contemporary Approaches to Modeling Biochemical Reactions. Genes Dev 24, 1861-1875. PMC2932968.
16. Spencer SL, and Sorger PK (2011). Measuring and Modeling Apoptosis in Single Cells. Cell 144, 926-939. PMC3087303
17. Millard BL, Niepel M, Menden MP, Muhlich JL, and Sorger PK (2011). Adaptive Informatics for Multifactorial and High-Content Biological Data. Nat Methods 8, 487-492. PMC3105758.
18. Aldridge BB, Gaudet S, Lauffenburger DA, and Sorger PK (2011). Lyapunov Exponents and Phase Diagrams Reveal Multi-Factorial Control over Trail-Induced Apoptosis. Mol Syst Biol 7, 553. PMID: 22108795.