A Noncanonical Frizzled2 Pathway Regulates Epithelial-mesenchymal Transition and Metastasis

Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, and MacBeath G (2014). A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis. Cell 159(4), 844-856. PMC4243058 PMID: 25417160. Abstract

Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that […]

Chromosome Instability Induced by Mps1 and p53 Mutation Generates Aggressive Lymphomas Exhibiting Aneuploidy-induced Stress

Foijer F, Xie SZ, Simon JE, Bakker PL, Conte N, Davis SH, Kregel E, Jonkers J, Bradley A, and Sorger PK (2014). Chromosome Instability Induced by Mps1 and P53 Mutation Generates Aggressive Lymphomas Exhibiting Aneuploidy-Induced Stress. Proc Natl Acad Sci U S A PMC4169945 PMID: 25197064. Abstract

Aneuploidy is a hallmark of human solid cancers […]

Failure Analysis of Clinical Trials to Test the Amyloid Hypothesis

Hyman BT, and Sorger P (2014). Failure Analysis of Clinical Trials to Test the Amyloid Hypothesis. Ann Neurol 76(2), 159-161. PMID: 25044380.

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LINCS Canvas Browser: Interactive Web App to Query, Browse and Interrogate LINCS L1000 Gene Expression Signatures

Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, and Ma’ayan A (2014). Lincs Canvas Browser: Interactive Web App to Query, Browse and Interrogate Lincs L1000 Gene Expression Signatures. Nucleic Acids Res PMID: 24906883. Abstract

For the Library of Integrated […]

Analysis of Growth Factor Signaling in Genetically Diverse Breast Cancer Lines

Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Muhlich JL, Schoeberl B, and Sorger PK (2014). Analysis of Growth Factor Signaling in Genetically Diverse Breast Cancer Lines. BMC Biol 12(1), 20. PMC4234128 PMID: 24655548. Abstract

BACKGROUND: Soluble growth factors present in the microenvironment play a major role in tumor development, invasion, […]

Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis

Kallenberger SM, Beaudouin J, Claus J, Fischer C, Sorger PK, Legewie S, and Eils R (2014). Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of Cd95-Induced Apoptosis. Sci Signal 7(316), ra23. PMC4208692 PMID: 24619646. Abstract

Apoptosis in response to the ligand CD95L (also known as Fas ligand) is initiated by caspase-8, which is activated […]

Decision-Tree Based Model Analysis for Efficient Identification of Parameter Relations Leading to Different Signaling States

Koch Y, Wolf T, Sorger PK, Eils R, and Brors B (2013). Decision-Tree Based Model Analysis for Efficient Identification of Parameter Relations Leading to Different Signaling States. PLoS ONE 8(12), e82593. PMC3867358 PMID: 24367526. Abstract

In systems biology, a mathematical description of signal transduction processes is used to gain a more detailed mechanistic understanding of […]

Metrics Other Than Potency Reveal Systematic Variation in Responses to Cancer Drugs

Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, and Sorger PK (2013). Metrics Other Than Potency Reveal Systematic Variation in Responses to Cancer Drugs. Nat Chem Biol 9(11), 708-714. PMC3947796 PMID: 24013279. Abstract

Large-scale analysis of cellular response to anticancer drugs typically focuses on variation in potency (half-maximum inhibitory concentration, (IC50)), assuming that it is […]

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, and Sorger PK (2013). Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines. Sci Signal 6(294), ra84. PMC3845839 PMID: 24065145. Abstract

Identifying factors responsible for variation in drug response is essential for the effective use […]

BID Preferentially Activates BAK While BIM Preferentially Activates BAX, Affecting Chemotherapy Response

Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, and Letai A (2013). BID Preferentially Activates BAK While BIM Preferentially Activates BAX, Affecting Chemotherapy Response. Mol Cell 51(6), 751-765. PMID: 24074954. Abstract

Apoptosis is a highly regulated form of cell death that controls normal homeostasis as […]