Funding
The research of the Sorger Lab is supported by the following grants:
R01 GM051464 (PI: Sorger)
National Institutes of Health
Biochemical and Genetic Analysis of Yeast Kinetochores
The overall goal of this study is the isolation and molecular characterization of the proteins that mediate binding and ATP-dependent translocation of S. cerevisiae kinetochores along microtubules.
R01 CA084179 (PI: Sorger)
National Institutes of Health
Cell and Tumor Genetics of Mitotic Arrest Checkpoints
The goal of this study is the genetic and biochemical analysis of the Mad1, Mad2 and Mps1 proteins in mitotic checkpoint control and in the maintenance of genomic stability in mice.
P50 GM068762 (PI: Sorger)
National Institutes of Health
Systems Biology of Cell Decision Processes
The goal of this multi-investigator proposal is to establish an interdisciplinary center for the study of cell decision process particularly in the area of programmed cell death. Funds to the Sorger lab support the study of cell signaling downstream of the EGF and TNF Receptors.
U54 CA112967 CCR (PI: Lauffenburger)
National Institutes of Health
Regulatory Networks in Cancer Initiation and Progression
The goal of this multi-investigator proposal is to establish a center for studying factors involved in tumor progression. The Sorger lab investigates the role of RTK mutations on the development of lung cancers in mice and human cells.
R01 GM068956 (PI: Sorger)
National Institutes of Health (Joint NIH-NSF Program)
Computation and Mechanical Modeling of Chromosome Dynamics
The goals of this study are to develop computational methods for analyzing chromosome motion in wild type and mutant yeast cells and to thereby link force generating processes to the activities of specific kinetochore proteins.